GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2077224 | 1 | rs2077224 | chr11:62197427 | ASRGL1 | chr11:62104774-62160885:+ | -0.29 | -4.3 | 4.07E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs4660306 | 1 | rs2077808 | chr1:45988115 | CCDC163P | chr1:45960581-45965646:- | -0.86 | -14.78 | 2.3E-26 | Homocysteine levels |
| THYM | cis | rs2120019 | 1 | rs2083731 | chr15:75368538 | PPCDC | chr15:75315927-75343066:+ | 0.26 | 4.77 | 6.63E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs6540731 | 1 | rs2087946 | chr1:212405396 | NEK2 | chr1:211836115-211848967:- | -0.16 | -4.42 | 2.59E-5 | Intelligence (childhood) |
| THYM | cis | rs9381040 | 1 | rs2093395 | chr6:41155026 | LOC221442 | chr6:41068773-41108567:+ | -0.36 | -5.29 | 7.68E-7 | Alzheimer's disease (late onset) |
| THYM | cis | rs9381040 | 1 | rs2093396 | chr6:41155000 | LOC221442 | chr6:41068773-41108567:+ | 0.36 | 5.29 | 7.68E-7 | Alzheimer's disease (late onset) |
| THYM | cis | rs1559040 | 1 | rs2112125 | chr2:54348030 | RTN4 | chr2:55199329-55277734:- | -0.51 | -4.25 | 4.97E-5 | Sudden cardiac arrest |
| THYM | cis | rs10461617 | 1 | rs2113078 | chr5:56087190 | C5orf35 | chr5:56205103-56213010:+ | 0.73 | 8.09 | 1.95E-12 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs2113079 | chr5:56157951 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.3E-14 | Type 2 diabetes |
| THYM | cis | rs7552404 | 1 | rs211718 | chr1:76106675 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.13 | 7.75E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs2120019 | 1 | rs2120019 | chr15:75334184 | PPCDC | chr15:75315927-75343066:+ | 0.27 | 4.85 | 4.8E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs9815354 | 1 | rs2128834 | chr3:41862645 | ULK4 | chr3:41288091-42003660:- | 1 | 10.95 | 1.58E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs2128835 | chr3:41862873 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs2130392 | 1 | rs2130392 | chr4:185639169 | CCDC111 | chr4:185570767-185616112:+ | 0.33 | 4.27 | 4.71E-5 | Kawasaki disease |
| THYM | cis | rs2130392 | 1 | rs2130392 | chr4:185639169 | MLF1IP | chr4:185615220-185655286:- | -0.33 | -7.29 | 9.16E-11 | Kawasaki disease |